Do you love meatloaf and want to make it perfectly every time? Preparing a delicious, flavorful meatloaf can be daunting – what temperature should I cook the loaf at and how long is too long in the oven? We have all had that ruined dinner due to our anxious guesswork! If you’ve been unconfident in cooking your own homemade meatloaf dinners, this blog post is for you. Read on for exactly how long to cook meatloaf at 375.
Contents
- 1 What is meatloaf?
- 2 Types of meatloaf
- 3 Nutrition information of meatloaf
- 4 What is the best temperature for cooking meatloaf?
- 5 Benefits of cooking meatloaf at 375 degrees
- 6 What is the optimal temperature to cook meatloaf?
- 7 How to cook meatloaf at 375?
- 8 How long to cook meatloaf at 375?
- 9 How to tell when your meatloaf is done?
- 10 Should you cover meatloaf with foil while cooking at 375?
- 11 Tips for making sure meatloaf turns out perfectly every time
- 12 How to store leftover meatloaf?
- 13 What to serve with meatloa?
- 14 The most common mistakes to avoid when baking meatloaf?
- 15 Food safety guidelines for serving and storing cooked meatloaf?
- 16 Some recipe with leftover meatloaf
- 17 Conclusion: How long to cook meatloaf at 375?
- 18 FAQs Meatloaf
- 18.1 Is it better to cook meatloaf at 350 or 375?
- 18.2 Can you cook a meatloaf at 300?
- 18.3 Should I cover my meatloaf when I bake it?
- 18.4 How long does it take to cook a 1 pound meatloaf at 375?
- 18.5 How long does it take to cook a 2lb meatloaf at 375 degrees?
- 18.6 Can you cook meatloaf at a lower temperature?
- 18.7 How long does it take to cook meatloaf at 400?
- 18.8 Can you overcook meatloaf?
- 18.9 Do you cover meatloaf when baking at 350?
- 18.10 Can you cook meatloaf at 200 degrees?
- 18.11 Do you cover meatloaf with foil when baking?
- 18.12 How long does it take to cook a 2lb meatloaf at 375?
- 18.13 How to tell when meatloaf is done without a thermometer?
What is meatloaf?
Meatloaf is a classic comfort food dish made by mixing ground meat (usually beef, pork, or a combination of both) with various ingredients such as breadcrumbs, eggs, onions, and spices. The mixture is then shaped into a loaf and baked in the oven. Meatloaf is a versatile dish that can be customized to one’s taste by adding different seasonings or toppings, such as ketchup or bacon.

Types of meatloaf
There are many variations of meatloaf, with different meats, spices, and fillings. Some variations include:
– Classic meatloaf: Made with ground beef and seasoned with onions, garlic, breadcrumbs, and ketchup.
– Barbecue meatloaf: A twist on classic meatloaf, made with BBQ sauce and topped with bacon.
– Turkey meatloaf: A leaner alternative to beef, mixed with spices, vegetables, and breadcrumbs.
– Vegetarian meatloaf: Made with meat substitutes such as tofu or lentils, and flavored with herbs and spices.
– Cheese-filled meatloaf: A decadent version, stuffed with cheese (often mozzarella) for gooey, melty goodness.
Nutrition information of meatloaf
Meatloaf is a hearty and filling comfort food dish that is loved by many. While the exact nutritional content of meatloaf can vary depending on the specific recipe and ingredients used, it is generally considered to be a high protein dish.
Beef and pork are both commonly used in meatloaf, which are good sources of protein, vitamin B12, and iron. However, meatloaf can also be made with ground turkey or chicken, which are leaner sources of protein.
Breadcrumbs and eggs are often used as binders in meatloaf, which can contribute to its carbohydrate and fat content. However, using whole wheat breadcrumbs and egg whites can make the dish slightly more nutritious.
Meatloaf can also be loaded with vegetables like onions, garlic, carrots, and celery, which can add vitamins and minerals to the dish. Additionally, using a tomato-based sauce or topping can provide additional nutrients like lycopene, a powerful antioxidant.

What is the best temperature for cooking meatloaf?
When it comes to cooking the perfect meatloaf, temperature is key. The optimal temperature for cooking a meatloaf is 375°F (190°C). Cooking your meatloaf at this temperature ensures that it cooks evenly and thoroughly without drying out.
Benefits of cooking meatloaf at 375 degrees
Cooking your meatloaf at 375°F (190°C) not only ensures that the loaf is cooked evenly and thoroughly, it also helps retain its moisture. This temperature is especially important when using lean ground beef or turkey as these meats tend to dry out quickly. Additionally, cooking your meatloaf at 375°F (190°C) will help it to hold its shape and have a texture that is neither too soft nor too tough.

What is the optimal temperature to cook meatloaf?
The optimal temperature to cook meatloaf is 375°F (190°C). Cooking meatloaf at higher temperatures and for longer periods of time can cause the exterior to become dry and the interior uncooked. It is important to cook meatloaf thoroughly to prevent the risk of foodborne illness. A meat thermometer can be used to check the internal temperature of the meatloaf, which should reach 160°F (71°C).
How to cook meatloaf at 375?
To cook meatloaf at 375°F, start by preheating your oven to the recommended temperature. While the oven is preheating, prepare your meatloaf mixture by combining ground meat with breadcrumbs, eggs, onions, garlic, spices, and any additional vegetables or seasonings that you prefer.
Once you have mixed all the ingredients together, transfer the mixture into a baking dish or loaf pan, and shape it into a loaf shape. You can brush the top of the meatloaf with a sauce of your choice, such as ketchup or barbecue sauce, to add extra flavor.
Place the meatloaf in the preheated oven and bake for approximately 45-60 minutes, depending on the thickness of your meatloaf. It is important to use a meat thermometer to check the internal temperature of the meatloaf, which should be 160°F (71°C) to ensure it is fully cooked. Avoid overcooking the meatloaf, as this can cause it to dry out.
Once the meatloaf is fully cooked, remove it from the oven and allow it to rest for about 10-15 minutes before slicing. This period of rest allows for the juices to redistribute throughout the meat and prevents the meatloaf from drying out. Serve the meatloaf with your favorite side dishes, such as mashed potatoes and steamed vegetables.
How long to cook meatloaf at 375?
How long to cook meatloaf at 375? When cooking meatloaf at 375°F, the cooking time can vary based on the thickness of the meatloaf. However, a general rule of thumb is to cook it for approximately 45-60 minutes. It is crucial to use a meat thermometer to check the internal temperature of the meatloaf, ensuring it has reached 160°F (71°C), the safe cooking temperature for ground meat.
Overcooked meatloaf can become dry and tough, so it is important to avoid leaving it in the oven for too long. Additionally, allowing the meatloaf to rest after cooking for 10-15 minutes is a crucial step as it allows the juices to redistribute, keeping the meatloaf moist and tender.
How to tell when your meatloaf is done?
One of the most important steps in cooking a meatloaf is determining when it is fully cooked. While the optimal cooking temperature and time can provide a general guide, there are a few other indicators you can look for to check if your meatloaf is done.
First, use a meat thermometer to check the internal temperature of the meatloaf, which should be 160°F (71°C) to ensure it is fully cooked. Insert the thermometer into the thickest part of the meatloaf, being careful not to touch the sides or bottom of the baking dish.
Another visual indicator of a cooked meatloaf is the appearance of the juices. Once the meatloaf is fully cooked, the juices should no longer be pink or red but instead be clear or a light yellow color. Cut into the center of the meatloaf and observe the juices that flow out.
Lastly, check the texture of the meatloaf. If it is still raw, the texture will be soft and mushy. A fully cooked meatloaf will have a firm texture and will hold its shape when sliced.
Should you cover meatloaf with foil while cooking at 375?
Covering your meatloaf with foil while cooking at 375°F is not necessary, but it can be helpful in certain circumstances. If you notice that the top of your meatloaf is becoming too brown before the interior is fully cooked, you can cover the dish with aluminum foil. This will help to trap moisture and prevent the top from burning, allowing the meatloaf to cook evenly.
However, if you are using a sauce or topping that you want to caramelize, such as ketchup, you may choose not to cover your meatloaf. If you decide to use foil, remove it during the last 10-15 minutes of cooking to allow the top to brown and caramelize. Keep in mind that the foilis not necessary for cooking meatloaf, so it is entirely up to personal preference and the specific recipe being used.

Tips for making sure meatloaf turns out perfectly every time
Now know how long to cook meatloaf at 375To make sure your meatloaf turns out perfectly every time, here are some tips to follow:
1. Use the right meat: Ground beef is the most commonly used meat in meatloaf recipes, but you can also use ground pork, turkey, or chicken. However, ground beef and pork are fattier and take longer to cook than ground chicken or turkey, so keep that in mind when selecting your meat.
2. Add moisture: Meatloaf can easily become dry if it lacks moisture. To prevent this, add ingredients like onions, garlic, or celery to the mixture, which adds moisture and flavor to the dish. Vegetables can also add more nutrition to the meatloaf, making it a healthier option.
3. Use a meat thermometer: A meat thermometer is a crucial tool for ensuring the meatloaf is cooked thoroughly. The internal temperature should reach 160°F (71°C) to prevent the risk of foodborne illness.
4. Let it rest: After removing the meatloaf from the oven, let it rest for 10-15 minutes to allow the juices to redistribute. This makes the meatloaf juicier and easier to slice.
5. Use a baking dish or loaf pan: To ensure that the meatloaf cooks evenly, use a baking dish or loaf pan with high sides. This will prevent the juices from overflowing and make it easier to take the meatloaf out of the pan.
How to store leftover meatloaf?
Storing leftover meatloaf is a common concern as many people often make more than they can eat in one sitting. To ensure that your meatloaf stays fresh and tasty, it is important to store it properly.
The first step is to let the leftover meatloaf cool down to room temperature. Once it has cooled, cut it into slices or portions that are easy to reheat. Wrapping the meatloaf in plastic wrap or aluminum foil helps to keep it moist and prevent it from drying out. Alternatively, you can store it in an airtight container.
Refrigerate the leftover meatloaf within two hours after it has been cooked. Beef, pork, and poultry can be stored in the fridge for up to four days. However, it is important to reheat the meatloaf to an internal temperature of 165°F (74°C) before eating.
For longer storage, you can freeze the leftover meatloaf. Tightly wrap the slices or portions in plastic wrap or aluminum foil, or place them in an airtight container before putting them in the freezer. Frozen meatloaf can be stored for up to three months. When reheating frozen meatloaf, thaw it first in the refrigerator and then reheat it to an internal temperature of 165°F (74°C) before eating.
What to serve with meatloa?
Meatloaf is a classic dinner option that pairs well with many side dishes. Try serving your meatloaf with mashed potatoes and gravy, green beans, corn, or roasted carrots. For a traditional pairing, serve your meatloaf with garlic mashed potatoes and brown gravy.

The most common mistakes to avoid when baking meatloaf?
When baking meatloaf, there are some common mistakes to avoid. The most important is to not overcook your meatloaf – this will cause it to dry out and become tough. Additionally, make sure you use the right amount of ingredients and mix them thoroughly before baking – too much or too little of an ingredient can throw off the consistency of the finished loaf. Finally, be sure to use a thermometer to ensure your meatloaf is cooked through – the internal temperature should read 160°F (71°C) before removing the loaf from the oven.
Food safety guidelines for serving and storing cooked meatloaf?
Once your meatloaf is cooked, be sure to follow the food safety guidelines for serving and storing. Let the meatloaf cool completely before attempting to slice it – this will help ensure that the slices retain their shape and are easier to portion. When transferring the loaf onto a plate or dish, use two large spatulas so you don’t lose any of the meat.
Some recipe with leftover meatloaf
Leftover meatloaf can be utilized in many different ways. Here are some ideas to help you repurpose your leftover meatloaf:
1. Meatloaf sandwiches – Slice the meatloaf and serve it between two slices of bread with your favorite toppings.
2. Meatloaf hash – Cube the meatloaf and fry it with potatoes, onions, and other vegetables for a flavorful breakfast dish.
3.Meatloaf muffins – Make mini meatloafs in a muffin tin for a fun, easy-to-eat meal.
4. Meatloaf lasagna – Layer leftover meatloaf with lasagna noodles and cheese for a hearty pasta dish.
5. Meatloaf quesadillas – Use leftover meatloaf as a filling in a quesadilla for a Tex-Mex twist on a classic dish.

Conclusion: How long to cook meatloaf at 375?
Cooking meatloaf can be intimidating, but with the right temperature and cooking time, you can make a delicious and perfectly cooked dish every time. When cooking meatloaf at 375°F, it should be cooked for approximately 45-60 minutes or until it reaches an internal temperature of 160°F (71°C) using a meat thermometer. Consider the type of meat used and the moisture content of the mixture when determining the optimal cooking time. Remember to let the meatloaf rest for 10-15 minutes after cooking to allow the juices to redistribute and prevent it from drying out. With these tips, you can make a juicy and flavorful meatloaf every time.
FAQs Meatloaf
Is it better to cook meatloaf at 350 or 375?
For a perfectly cooked meatloaf, it’s essential to cook it at the right temperature. Ideally, cooking your meatloaf at 375°F (190°C) is recommended to ensure it’s moist and tender inside and evenly cooked throughout. If you choose to cook it at 350°F (175°C), you run the risk of it being dry, and it will take longer to cook. Aim for a cook time of 45-60 minutes, or until the internal temperature of the meatloaf reaches 160°F (71°C) for the best results. Don’t forget to use a meat thermometer to verify the temperature!
Can you cook a meatloaf at 300?
Yes. Cooking smaller 1-pound meatloaves at a lower temperature of 300 F to 325 F for an additional 10 to 12 minutes can give you a moister and juicier end result. This gentler cooking method helps to minimize moisture loss during the cooking process.
Should I cover my meatloaf when I bake it?
Although it’s not necessary, covering your meatloaf when baking can ensure even cooking and prevent the top from over-browning. Aluminum foil is recommended as a covering and can be removed during the last 10-15 minutes for browning. However, if you’re using a sauce or topping that you want to caramelize, such as ketchup, you may want to skip the covering. Ultimately, the choice to cover your meatloaf is a personal one, considering your preference and recipe.
How long does it take to cook a 1 pound meatloaf at 375?
To cook a 1-pound meatloaf at 375°F, allow roughly 30-40 minutes or until the inside temperature reaches 160°F (71°C). However, the cooking duration may differ due to factors such as meat type and thickness. It’s essential to use a meat thermometer to determine the precise cooking time for your recipe. To avoid drying out, let the meatloaf rest for 10-15 minutes after cooking, allowing the juices to redistribute. Don’t forget this vital step.
How long does it take to cook a 2lb meatloaf at 375 degrees?
For a perfectly cooked 2-pound meatloaf, bake at 375°F for 60-75 minutes until the internal temperature reaches 160°F (71°C) as measured by a meat thermometer. Be aware that cooking time may fluctuate based on meat type and loaf thickness. To guarantee accuracy, use a meat thermometer to determine when your specific recipe is done. After cooking, allow the meatloaf to rest for 10-15 minutes to allow the juices to redistribute and avoid drying out.
Can you cook meatloaf at a lower temperature?
Cooking meatloaf at a lower temperature may take longer, but it can lead to a juicier and tenderer dish. The downside is that it might lack the satisfying crispy texture of meatloaf cooked at a higher temperature. To ensure safety, use a meat thermometer and make sure it reaches an internal temperature of 160°F (71°C) to avoid the risk of foodborne illness. Keep in mind that the cooking time and temperature will vary depending on the recipe and meat type you’re using.
How long does it take to cook meatloaf at 400?
Cooking meatloaf to perfection requires the right temperature and cooking time. Avoid dry exteriors and uncooked interiors by setting your oven to 375°F (190°C) instead of 400°F. It should take about 45-60 minutes to cook, but always use a meat thermometer to ensure it reaches an internal temperature of at least 160°F (71°C). Remember, cooking times may vary based on your recipe and the type of meat. And be sure to let it rest for 10-15 minutes after cooking to let the juices redistribute. Invest in an oven-safe meat thermometer for accurate cooking temperature readings without opening the oven.
Can you overcook meatloaf?
Meatloaf can become dry and tough when overcooked, but there are easy ways to avoid this. Use a meat thermometer to ensure the internal temperature reaches 160°F (71°C) and don’t leave it in the oven for too long. After cooking, let the meatloaf rest for 10-15 minutes to keep the juices inside and prevent drying out. To ensure the perfect texture, check that the meatloaf is firm and holds its shape after slicing. With these tips, you can make a delicious and succulent meatloaf every time.
Do you cover meatloaf when baking at 350?
Want a perfectly cooked meatloaf every time? Cover it while baking at 350°F (175°C) with aluminum foil to trap moisture and prevent burning. But, the decision to cover the dish is up to personal preference and recipe. Make sure to use a meat thermometer and check the internal temperature, which should reach 160°F (71°C) to ensure safety. And don’t forget to let the meatloaf rest for 10-15 minutes after cooking to maximize flavor.
Can you cook meatloaf at 200 degrees?
To perfectly smoke your meatloaf, place it on a covered grill and maintain an indirect heat of approximately 200 degrees. Cook until the interior temperature of the meatloaf registers 140 degrees on an instant-read thermometer.
Do you cover meatloaf with foil when baking?
Covering your meatloaf with foil while baking is unnecessary. In fact, it can hinder the browning process and make the loaf too moist.
How long does it take to cook a 2lb meatloaf at 375?
Cook a 2lb meatloaf to perfection in just one hour at 375°F (190°C). Easily determine its readiness by inserting a thermometer into the center – once it reaches 160°F (71°C), you can be confident it’s fully cooked.
How to tell when meatloaf is done without a thermometer?
Determining the doneness of your meatloaf without a thermometer is possible. A simple method involves gently pressing the top of the loaf, which should exhibit little resistance and spring back.

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