These Celebrities Admitted To Taking Ozempic, And Some Had Terrible Side Effects

Ozempic has become the celebrity “supporting actor” nobody auditioned for, yet somehow keeps showing up in every headline. One week it’s a whispered rumor, the next week a famous person is saying, “Yup, I tried it,” and thenplot twistadding, “Also, it made me feel like a haunted washing machine.”

This article is a reality-check tour of public, on-the-record admissions from celebrities who’ve said they used Ozempic (or talked about “Ozempic-type” GLP-1 medications) and what happened nextespecially the side effects that were bad enough to make some of them stop. We’ll also zoom out and explain what Ozempic is actually for, why it can cause intense stomach issues, and why chasing a celebrity trend with a prescription drug is a spectacularly bad ideaparticularly for teens.

Important: Ozempic is a prescription medication. This is informational content, not medical advice. If you’re a minor, don’t take cues from Hollywood. Talk with a licensed clinician and a parent/guardian about any health concerns.

Ozempic 101: What It Isand Why It’s Everywhere

Ozempic is the brand name for semaglutide, a medication that belongs to a class called GLP-1 receptor agonists. In plain English: it helps manage blood sugar in people with type 2 diabetes, and it often reduces appetite and slows how quickly food leaves the stomachone reason many people lose weight while taking it.

In celebrity and social media conversations, “Ozempic” is often used as a catch-all for multiple GLP-1 (and similar) medications. That’s like calling every streaming service “Netflix.” Convenient? Yes. Accurate? Not always.

Two key points get lost in the hype:

• Ozempic is primarily approved for type 2 diabetes. (Some people may be prescribed it off-label for weight management, depending on clinical judgment and availability.)
• Side effects are realand sometimes intense. The same “slows your digestion” mechanism that can help with satiety can also trigger nausea, vomiting, constipation, or abdominal pain in some people.

Now, let’s talk about the part celebrities keep bringing up: the “it worked… until it didn’t” side of the story.

Ozempic Side Effects: The Common Ones, the Concerning Ones, and the “Call Your Doctor” Ones

According to official prescribing information, the most common Ozempic side effects are gastrointestinal: nausea, vomiting, diarrhea, stomach (abdominal) pain, and constipation. These can range from mildly annoying to “I can’t look at a saltine cracker without gagging.”^[11]

Ozempic’s labeling also includes important warnings and precautions. Some side effects and risks discussed in official materials and major medical resources include:

• Severe stomach problems (sometimes reported as severe or persistent GI symptoms).^[11][12]
• Gallbladder problems (seek care if symptoms occur).^[11][12]
• Pancreatitis warning signs (severe abdominal pain, sometimes with vomiting, needs urgent evaluation).^[11][12]
• Kidney issues related to dehydration if vomiting/diarrhea are severe and ongoing.^[11]
• Low blood sugar risk can increase when combined with certain diabetes meds (this is mainly relevant to people being treated for diabetes).^[11]
• Boxed warning about thyroid C-cell tumors in rodents and related cautions (human relevance is not confirmed, but the warning exists).^[11]

Harvard Health and other medical sources emphasize something that feels obvious but gets forgotten in trend-culture: if side effects become severeespecially persistent vomiting/diarrhea, intense abdominal pain, inability to pass gas or have bowel movements, or jaundicedon’t “power through it.” Get medical help.^[13]

Okay. With that foundation in place, let’s get to the celebrities who actually said the quiet part out loud.

Celebrities Who Publicly Admitted Taking Ozempicand What They Said Happened

To be crystal clear: this list focuses on public admissions and reputable reportingnot speculation, not “body language analysis,” and not the internet’s favorite sport: guessing someone’s prescription based on a cheekbone.

1) Amy Schumer: “I looked great”… but felt awful

Amy Schumer has been unusually blunt (and funny, because she’s Amy Schumer) about trying Ozempic and having a rough time. She described being essentially knocked out by side effectsnausea, vomiting, and low energydespite acknowledging that other people tolerate it fine.^[1]

Why it matters: Her story is the poster child for variability. Two people can take the same medication and have dramatically different experiences. In the Ozempic conversation, that means one person is living their best “quiet food noise” life, while another is bargaining with the universe over a bowl of plain rice.

2) Chelsea Handler: Took it without realizing itand then felt sick

Chelsea Handler said she was given Ozempic and didn’t realize what she was taking at first. She later described feeling nauseous and connected it to the medication once she understood what it was.^[2]

Why it matters: Beyond the celebrity angle, this highlights a basic safety principle: you should know exactly what you’re taking and why. “Surprise semaglutide” should not be a thing.

3) Sharon Osbourne: Rapid weight loss, nausea, and regret… sort of

Sharon Osbourne has talked openly about using Ozempic and losing a significant amount of weight. She also described nausea and later expressed concern about losing too much and struggling to regain weight, even saying she’d like to put some back on.^[3]

Why it matters: Her experience is a reminder that “weight loss” isn’t automatically “health gain.” Losing weight too quicklyor overshooting what feels healthy for your bodycan be physically and emotionally unsettling.

4) Stephen Fry: Vomiting multiple times a day and stopping the drug

Stephen Fry said Ozempic initially curbed appetite, but side effects became overwhelminghe described severe nausea and frequent vomitingso he stopped taking it.^[4]

Why it matters: This is the “terrible side effects” category in neon lights. Some people truly can’t tolerate the GI impact, and quitting isn’t a failureit’s a medical decision.

5) Jennifer Fessler: Hospitalized with severe constipation/impacted bowel

Real Housewives of New Jersey star Jennifer Fessler shared that weight-loss injections in the Ozempic/semaglutide orbit led to severe constipation and an impacted bowel, sending her to the hospitalyet she also said she continued treatment afterward.^[5]

Why it matters: This is a real-world example of a side effect that isn’t just “ugh, nausea,” but a serious complication requiring medical attention. It also shows the complicated cost-benefit decisions some patients make with their clinicians.

6) Caroline Stanbury: “Projectile vomiting” after mixing alcohol and Ozempic

Real Housewives of Dubai star Caroline Stanbury described becoming violently sick after drinking alcohol while taking Ozempic, blaming the combination for an intense vomiting episode.^[6]

Why it matters: Stanbury’s story aligns with a broader medical reality: Ozempic already affects the GI system, and alcohol can irritate it further. Some people discover this the hard wayusually in a public place, with terrible lighting, and witnesses who will never let them forget.

7) Chrissy Teigen: Used Ozempic after miscarriage; appetite suppression felt uncomfortable

Chrissy Teigen shared that she took Ozempic after her miscarriage, describing a complicated emotional context and noting that the medication suppressed her appetite in a way that felt uncomfortableespecially given her relationship with food and cooking.^[7]

Why it matters: Teigen’s story underlines something the “before-and-after” discourse ignores: weight, body image, and medication choices often sit on top of grief, stress, depression, postpartum changes, and trauma. A prescription can affect the body, but it can’t untangle the emotional thread alone.

8) Rebel Wilson: Tried Ozempic as one tool in maintaining her size

Rebel Wilson said she briefly tried Ozempic as one method involved in her weight journey and maintenance, while also discussing appetite and cravings.^[8]

Why it matters: Her comments reflect how some people use these medications as one piece of a broader strategy. It also illustrates why “Ozempic did it” and “Ozempic did nothing” can both be truepeople’s biology and behavior patterns differ.

9) Tracy Morgan: Uses Ozempic for diabetes and says it cut his appetite

Tracy Morgan publicly discussed taking Ozempic in the context of diabetes management and later clarified that jokes about weight gain were just jokes. He also said it helped reduce his appetite.^[9]

Why it matters: Morgan’s story highlights the original medical lane of Ozempic: type 2 diabetes. Celebrity chatter often frames Ozempic as purely aesthetic, but many people take it for metabolic healthand the public conversation can blur that line.

10) James Corden: Tried it, but said it didn’t address his real issue

James Corden said he tried Ozempic but didn’t find it effective for him because his eating patterns weren’t driven by hunger. He framed his relationship with food as more emotional and habitual than appetite-based.^[10]

Why it matters: This is a crucial point that rarely goes viral: appetite suppression doesn’t automatically solve emotional eating, stress eating, or “I’m not hungry but I want a king-size chocolate bar” eating. (Many of us have met that bar. Some of us are on a first-name basis.)

So… Is Ozempic “Worth It”? The Honest Answer Is: It Depends

If you expected a dramatic, one-size-fits-all verdictcongrats, you are emotionally prepared for clickbait. But reality is messier:

• Some people report life-changing benefits, especially when Ozempic is used for its intended medical purposes under supervision.
• Some people experience side effects that are unpleasant but manageable.
• Some people experience side effects that are severe enough to stop treatment or seek urgent care.

What the celebrity stories addbeyond the gossip factoris visibility: they show that the “Ozempic experience” isn’t a single story. It’s a range.

The Ozempic Experience: What These Stories Have in Common (500+ Words)

When you line up these celebrity admissions side-by-side, a few patterns show uppatterns that also match what official materials and major medical resources say about GLP-1 medications.

First: the stomach is the main character. Over and over, the stories pivot on GI side effects: nausea, vomiting, constipation, abdominal pain, and that vague sense of “my digestive system has unionized and is now striking.” Official information lists GI issues as the most common side effects, and multiple celebrities basically provided the “celebrity audiobook” version of that warning.^[11][12]

Second: tolerance is wildly individual. Amy Schumer’s experience sounded brutal, while Tracy Morgan described Ozempic as working well for him. One person tries it and quits fast; another tries it, struggles, adjusts, and keeps going. That difference isn’t just willpowerit’s biology, dosing decisions, other medical conditions, other medications, and plain old variability. This is why copying a famous person’s medication choice is like copying a famous person’s tattoo: it might look cool on them, but you’re the one who has to live with it.

Third: “weight loss” isn’t always a victory lap. Sharon Osbourne and Chrissy Teigen both illustrated an under-discussed side: losing weight can come with fear, discomfort, grief, or a feeling of losing control. Sometimes people want to regain weight. Sometimes the body changes remind them of painful events. Sometimes appetite suppression feels less like “freedom” and more like living with a dimmer switch on a part of life they normally enjoyespecially for people whose careers or identities are wrapped up in food, performance, or public appearance.^[3][7]

Fourth: behavior still matters, because hunger isn’t the only driver. James Corden’s comments are a useful counterweight to magical thinking. If your eating is rooted in stress, habit, comfort, or routine, a medication that reduces hunger may not touch the real trigger. That doesn’t mean the drug is “bad” or “fake.” It means your situation is more complex than an appetite dial.^[10]

Fifth: there’s a big “do not try this at home” sign for teens. Teen bodies and brains are still developing, and health decisions should be made with qualified clinicians and family supportnot the comment section. Celebrity culture can make medical treatment feel like a shortcut or a beauty hack. But Ozempic is a prescription drug with real risks and real contraindications, and official resources stress that serious side effects require medical attention.^[11][13]

Finally: the healthiest takeaway is the least viral onetalk to professionals, not rumor mills. If you have type 2 diabetes, obesity, or another medical condition where a GLP-1 may be appropriate, the best next step is a conversation with a licensed healthcare professional who can weigh benefits, risks, and alternatives. If you don’t have a medical indication and you’re tempted because a celebrity made it sound easy, remember that celebrities also make “easy” look like a full-time job with a glam squad.

Conclusion

Ozempic didn’t become famous because it’s flashy. It became famous because it can be effectiveand because, for some people, the side effects are no joke. The celebrities who’ve admitted using it (and the ones who described terrible side effects) unintentionally did the public a favor: they exposed the gap between the fantasy (“instant transformation!”) and the reality (“this medication changes how your body works, and sometimes your body complains loudly”).

If there’s one smart way to read these stories, it’s this: treat Ozempic like what it isa serious prescription medicationnot a trend. And treat your health like something more valuable than an algorithm’s attention span.

References (for editorial verification)

1. Amy Schumer describes being bedridden with nausea/vomiting after trying Ozempic (PEOPLE).
2. Chelsea Handler says she “didn’t know” she was on Ozempic and felt nauseous (PEOPLE).
3. Sharon Osbourne discusses Ozempic-related weight loss and difficulties regaining weight (PEOPLE).
4. Stephen Fry recounts vomiting multiple times a day while on Ozempic (PEOPLE).
5. Jennifer Fessler says Ozempic-type injections led to an impacted bowel / severe constipation and hospitalization (PEOPLE).
6. Caroline Stanbury recalls projectile vomiting after alcohol while on Ozempic (PEOPLE).
7. Chrissy Teigen says she took Ozempic after miscarriage and found appetite suppression uncomfortable (PEOPLE).
8. Rebel Wilson says she briefly tried Ozempic as one method in her weight journey (ABC News / GMA).
9. Tracy Morgan clarifies Ozempic comments and says it reduced his appetite (PEOPLE).
10. James Corden says Ozempic didn’t really work for him because his eating wasn’t hunger-driven (PEOPLE).
11. Ozempic label information including common side effects and boxed warning (DailyMed, NLM).
12. Ozempic official site side effects overview (Ozempic.com).
13. GLP-1 side effects and when to seek medical attention (Harvard Health).
14. Medical context on Ozempic + alcohol and GI side effects (Healthline).